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Literature summary for 7.1.1.2 extracted from

  • Verkaart, S.; Koopman, W.J.; van Emst-de Vries, S.E.; Nijtmans, L.G.; van den Heuvel, L.W.; Smeitink, J.A.; Willems, P.H.
    Superoxide production is inversely related to complex I activity in inherited complex I deficiency (2007), Biochim. Biophys. Acta, 1772, 373-381.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
rotenone chronic rotenone treatment (100 nanomol, 72 h) increases fully assembled complex I in human skin fibroblasts Homo sapiens

Application

Application Comment Organism
medicine superoxide production is increased in children with inherited complex I deficiency, which is primarily a consequence of the reduction in cellular complex I activity and not of a further leakage of electrons from mutationally malformed complexes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
rotenone reduces complex I activity, which is accompanied by increasing production of cellular superoxide Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast fully assembled complex I is decreased in patient skin fibroblasts Homo sapiens
-

Synonyms

Synonyms Comment Organism
complex I
-
Homo sapiens
NADH:ubiquinone oxidoreductase
-
Homo sapiens