Activating Compound | Comment | Organism | Structure |
---|---|---|---|
rotenone | chronic rotenone treatment (100 nanomol, 72 h) increases fully assembled complex I in human skin fibroblasts | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | superoxide production is increased in children with inherited complex I deficiency, which is primarily a consequence of the reduction in cellular complex I activity and not of a further leakage of electrons from mutationally malformed complexes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rotenone | reduces complex I activity, which is accompanied by increasing production of cellular superoxide | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin fibroblast | fully assembled complex I is decreased in patient skin fibroblasts | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Homo sapiens |
NADH:ubiquinone oxidoreductase | - |
Homo sapiens |