Literature summary for 7.1.1.2 extracted from

Calabrese, V.; Mancuso, C.; Ravagna, A.; Perluigi, M.; Cini, C.; De Marco, C.; Butterfield, D.A.; Stella, A.M.
In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state (2007), J. Neurochem., 101, 709-717.

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Activating Compound

Activating Compound	Comment	Organism	Structure
L-Dopa	enhances nigral mitochondrial complex I expression and activity. Significant increase at 6 h, with maximal values at 24 h, compared with control animals, in absence of concomitant changes in the expression or activity of complex IV	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
substantia nigra	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
complex I	-	Rattus norvegicus
NADH-CoQ1 reductase	-	Rattus norvegicus

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Release 2023.1 (January 2023)