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Literature summary for 7.1.1.2 extracted from

  • Abe, M.; Kubo, A.; Yamamoto, S.; Hatoh, Y.; Murai, M.; Hattori, Y.; Makabe, H.; Nishioka, T.; Miyoshi, H.
    Dynamic function of the spacer region of acetogenins in the inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I) (2008), Biochemistry, 47, 6260-6266.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
(5S)-3-[4-[(E)-(4-[[(4R)-4-hydroxy-4-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]butyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
 Bos taurus
(5S)-3-[4-[(E)-(4-[[(7R)-7-hydroxy-7-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]heptyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
 Bos taurus
(5S)-3-[4-[(Z)-(4-[[(4R)-4-hydroxy-4-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]butyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
 Bos taurus
(5S)-3-[4-[(Z)-(4-[[(7R)-7-hydroxy-7-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl]heptyl]oxy]phenyl)diazenyl]benzyl]-5-methylfuran-2(5H)-one
-
 Bos taurus
bis-tetrahydrofuran acetogenin the additional methylenes enhance the hydrophobicity of the spacer region, which may be thermodynamically advantageous for bringing the polar gamma-lactone ring into the membrane-embedded segment of complex I Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + ubiquinone Bos taurus
-
 NAD+ + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information complex I also shows NADH oxidase activity Bos taurus ?
-
 ?
NADH + H+ + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?
NADH + H+ + ubiquinone-1
-
 Bos taurus NAD+ + ubiquinol-1
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Bos taurus
NADH-ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus