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Literature summary for 7.1.1.2 extracted from

  • Kalashnikov, D.S.; Grivennikova, V.G.; Vinogradov, A.D.
    Submitochondrial fragments of brain mitochondria: general characteristics and catalytic properties of NADH:ubiquinone oxidoreductase (complex I) (2011), Biochemistry (Moscow), 76, 209-216.
    View publication on PubMed
Search for more literature for 7.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
alamethicin slight stimulation Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
DTNB
-
 Sus scrofa
piericidin specific inhibitor of ubiquinone reduction Sus scrofa
rotenone specific inhibitor of ubiquinone reduction Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane activities of submitochondrial fragments from heart and brain, overview Sus scrofa 5743
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ iron-sulfur center Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + ubiquinone + 6 H+[side 1] Sus scrofa
-
 NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-
heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hexaammineruthenium (III) chloride, i.e. HAR, can act as artificial electron acceptor. The rate of NADH oxidation by the artificial electron acceptor HAR is about 10fold higher than NADH oxidase activity and is insensitive to rotenone and piericidin Sus scrofa ?
-
 ?
NADH + ubiquinone + 6 H+[side 1]
-
 Sus scrofa NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Sus scrofa
NADH:HAR (III) reductase
-
 Sus scrofa
NADH:ubiquinone oxidoreductase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25 30 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADH the NADH binding site is located in the matrix of mitochondria and their inner membrane is impermeable for NADH Sus scrofa