Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP-ribose | - |
Bos taurus | |
ATP | - |
Bos taurus | |
additional information | NADH, ATP, ADP and ADP-ribose stimulate the enzyme reactions, indicating that the positively-charged acceptors interact with their negatively charged phosphates. In contrast to direct O2 reduction the rate is stimulated, not inhibited, by high NADH concentrations. When NADH, ADP, ATP and ADP-ribose bind to the reduced flavin they stimulate paraquat and HAR reduction, but inhibit FeCN, APAD+ and O2 reduction. Adenosine, which lacks phosphates, does not stimulate the reaction with hexaammineruthenium(III), HAR, ternary mechanism of HAR and paraquat reduction,overview | Bos taurus | |
NADH | - |
Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | when NADH, ADP, ATP and ADP-ribose bind to the reduced flavin they stimulate paraquat and HAR reduction, but inhibit FeCN, APAD+ and O2 reduction | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Bos taurus | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + ubiquinone + 6 H+[side 1] | Bos taurus | - |
NAD+ + ubiquinol + 7 H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the positively-charged electron acceptors paraquat and hexaammineruthenium(III) react with the nucleotide-bound reduced flavin in complex I, by an unusual ternary mechanism, overview. The mechanism for paraquat reduction defines another mechanism for superoxide production by complex I by redox cycling | Bos taurus | ? | - |
? | |
NADH + ubiquinone + 6 H+[side 1] | - |
Bos taurus | NAD+ + ubiquinol + 7 H+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Bos taurus |
NADH:ubiquinone oxidoreductase | - |
Bos taurus |
respiratory complex I | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
physiological function | the flavin mononucleotide in complex I catalyzes NADH oxidation, O2 reduction to superoxide, and the reduction of several artificial electron acceptors | Bos taurus |