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Literature summary for 7.1.1.3 extracted from
- Glutamate-286 mutants of cytochrome bo-type ubiquinol oxidase from Escherichia coli: influence of mutations on the binuclear center structure revealed by FT-IR and EPR spectroscopies (1997), FEBS Lett., 416, 247-250.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E286A | inactive | Escherichia coli |
| E286D | the mutant retains 31% of the wild type activity | Escherichia coli |
| E286Q | the mutant shows 4% activity compared to the wild type enzyme and is unable to bind azide ions | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyanide | - |
Escherichia coli |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Escherichia coli | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | the enzyme is a heme-copper terminal oxidase | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli GO103 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ubiquinol-1 + O2 + H+/in | - |
Escherichia coli | ubiquinone-1 + H2O + H+/out | - |
? | |
| ubiquinol-1 + O2 + H+/in | - |
Escherichia coli GO103 | ubiquinone-1 + H2O + H+/out | - |
? | |
| ubiquinol-8 + O2 + H+/in | - |
Escherichia coli | ubiquinone-8 + H2O + H+/out | - |
? | |
| ubiquinol-8 + O2 + H+/in | - |
Escherichia coli GO103 | ubiquinone-8 + H2O + H+/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cytochrome bo-type ubiquinol oxidase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | hemes B and O | Escherichia coli | |
| ubiquinol-8 | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | cytochrome bo-type ubiquinol oxidase in the aerobic respiratory chain of Escherichia coli catalyzes the reduction of dioxygen to water with ubiquinol-8, and utilizes the redox reactions to drive vectorial translocation of protons across the cytoplasmic membrane | Escherichia coli |
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