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Literature summary for 7.1.1.8 extracted from

  • Rotsaert, F.A.; Ding, M.G.; Trumpower, B.L.
    Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin (2008), Biochim. Biophys. Acta, 1777, 211-219.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.8

Protein Variants

Protein Variants Comment Organism
L198F mutation in the yeast bc1 complex conferrs resistance to ilicicolin H Saccharomyces cerevisiae
Q22E mutation in the yeast bc1 complex conferrs resistance to ilicicolin H Saccharomyces cerevisiae
Q22T mutation in the yeast bc1 complex conferrs resistance to ilicicolin H Saccharomyces cerevisiae
S20T mutation in the yeast bc1 complex conferrs resistance to ilicicolin H Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
Antimycin with one equivalent of antimycin more than 90% of activity is inhibited Bos taurus
Antimycin effective inhibitor Paracoccus denitrificans
Antimycin with one equivalent of antimycin more than 90% of activity is inhibited Saccharomyces cerevisiae
funiculosin weak Bos taurus
funiculosin weak Paracoccus denitrificans
funiculosin weak Saccharomyces cerevisiae
ilicicolin H weak inhibitor, IC50 is above 100 nM Bos taurus
ilicicolin H weak inhibitor Paracoccus denitrificans
ilicicolin H potent inhibitor. S20T, Q22E, Q22T and L198F mutations in the yeast bc1 complex conferr resistance to ilicicolin H Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Paracoccus denitrificans
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquinol + 2 ferricytochrome c
-
 Paracoccus denitrificans ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?
ubiquinol + 2 ferricytochrome c
-
 Saccharomyces cerevisiae ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?
ubiquinol + 2 ferricytochrome c
-
 Bos taurus ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome bc1 complex
-
 Paracoccus denitrificans
cytochrome bc1 complex
-
 Saccharomyces cerevisiae
cytochrome bc1 complex
-
 Bos taurus