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Literature summary for 7.1.1.8 extracted from

  • Bazil, J.N.; Vinnakota, K.C.; Wu, F.; Beard, D.A.
    Analysis of the kinetics and bistability of ubiquinol:cytochrome c oxidoreductase (2013), Biophys. J., 105, 343-355.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.8

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state equation for the six-state system model, substrate binding affinities under different conditions, overview Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Mammalia 5743
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ Rieske iron-sulfur protein Mammalia
Mg2+ lowers the substrate binding affinities Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
quinol + 2 ferricytochrome c Mammalia
-
 quinone + 2 ferrocytochrome c + 2 H+
-
 ?
ubiquinol + 2 ferricytochrome c Mammalia
-
 ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
quinol + 2 ferricytochrome c
-
 Mammalia quinone + 2 ferrocytochrome c + 2 H+
-
 ?
ubiquinol + 2 ferricytochrome c
-
 Mammalia ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
bc1 complex
-
 Mammalia
ubiquinol:cytochrome c oxidoreductase
-
 Mammalia

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mammalia

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mammalia

General Information

General Information Comment Organism
additional information model of the bc1 complex for mammalian mitochondria incorporating the major redox centers near the Qo- and Qi-site of the enzyme, and including the pH-dependent redox reactions, overview. The model consists of six distinct states characterized by the mobile electron distribution in the enzyme Mammalia
physiological function the bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane. The complex is also implicated in the generation of reactive oxygen species under certain conditions and is thus a contributor to cellular oxidative stress Mammalia