Literature summary for 7.1.1.9 extracted from

Faxen, K.; Salomonsson, L.; Adelroth, P.; Brzezinski, P.
Inhibition of proton pumping by zinc ions during specific reaction steps in cytochrome c oxidase (2006), Biochim. Biophys. Acta, 1757, 388-394.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Zn2+	reaction of enzyme in detergent solution and reconstituted in phospholipid vesicles. At concentrations of Zn2+ below 0.25 mM at the outside of the vesicles, transistion rates between intermediates is not altered. Zn2+ ions bind on both sides of the enzyme and binding at the proton output side selectively impairs proton release during the transition of peroxy intermediate to oxo-ferryl intermediate	Cereibacter sphaeroides

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Cereibacter sphaeroides	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ascorbate + O2	reaction of enzyme in detergent solution and reconstituted in phospholipid vesicles	Cereibacter sphaeroides	? + H2O	-	?

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Release 2023.1 (January 2023)