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Literature summary for 7.1.1.9 extracted from
- Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H2637-H2645.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | after 30 min of ischemia and 120 min of reperfusion, total COI levels decrease in the left ventricular regions at risk by 72%. Subunit Va is also downregulated by 42% following prolonged ischemia-reperfusion in the left ventricular regions at risk. Cardiac ischemic preconditioning administered before ischemia-reperfusion reduces the loss of COI approximately 30% and prevents COVa losses completely. No losses in subunits Vb and VIIa following ischemia-reperfusion alone, but significant losses occur when cardiac ischemic preconditioning is administered before prolonged ischemia-reperfusion. Delivery of a cell-permeable PKC-epsilon translocation inhibitor to isolated rat hearts before prolonged ischemia-reperfusion dramatically increases COI loss | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
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Release 2023.1 (January 2023)
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