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Literature summary for 7.1.1.9 extracted from
- Impact of chronic subthalamic high-frequency stimulation on metabolic basal ganglia activity: a 2-deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinsons disease (2007), Eur. J. Neurosci., 25, 1492-1500.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | chronic high-frequency stimulation of the subthalamic nucleus increases COI mRNA expression, suggesting global activation of globus pallidus internalis neurons | Macaca fascicularis |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | simultaneous decrease in 2-deoxyglucose uptake and increase in COI mRNA expression are difficult to reconcile with the current model of basal ganglia function and suggest that the mechanisms by which high-frequency stimulation of the subthalamic nucleus exerts its clinical benefits are more complex than a simple reversal of abnormal activity in the subthalamic nucleus and its targets | Macaca fascicularis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca fascicularis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| globus pallidus | - |
Macaca fascicularis | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COI | - |
Macaca fascicularis |
| cytochrome oxidase subunit 1 | - |
Macaca fascicularis |
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Release 2023.1 (January 2023)
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