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Literature summary for 7.1.1.9 extracted from

  • Samavati, L.; Lee, I.; Mathes, I.; Lottspeich, F.; Huettemann, M.
    Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase (2008), J. Biol. Chem., 283, 21134-21144.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Application

Application Comment Organism
drug development tumor necrosis factor alpha-mediated CcO inhibition leads to tissue dysoxia, which suppresses aerobic ATP production and causes a shift to the glycolytic pathway. Kinases and phosphatases involved in reversible tumor necrosis factor alpha-mediated CcO phosphorylation may be promising targets for drug development because they act on an end point of cell signaling Mus musculus
drug development tumor necrosis factor alpha-mediated CcO inhibition leads to tissue dysoxia, which suppresses aerobic ATP production and causes a shift to the glycolytic pathway. Kinases and phosphatases involved in reversible tumor necrosis factor alpha-mediated CcO phosphorylation may be promising targets for drug development because they act on an end point of cell signaling Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Tumor necrosis factor alpha leads to an ca. 60% reduction in CcO activity in hepatocyte homogenates. Shows no direct effect on CcO activity using purified CcO. CcO isolated after tumor necrosis factor alpha treatment shows tyrosine phosphorylation on CcO catalytic subunit I and is ca. 50 and 70% inhibited at high cytochrome c concentrations in the presence of allosteric activator ADP and inhibitor ATP, respectively Bos taurus
Tumor necrosis factor alpha leads to reduction in CcO activity in hepatocyte homogenates. Shows no direct effect on CcO activity using isolated mitochondria CcO Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Mus musculus 5743
-
mitochondrial inner membrane
-
 Bos taurus 5743
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
H2.35 cell
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
hepatocyte
-
 Bos taurus
-

Storage Stability

Storage Stability Organism
-80°C, 20 mM Tris-Cl buffer, pH 7.4, 250 mM sucrose, 2 mM EDTA Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reduced Bos taurus cytochrome c + O2
-
 Mus musculus oxidized Bos taurus cytochrome c + H2O
-
 ?
reduced Bos taurus cytochrome c + O2
-
 Mus musculus C57BL/6 oxidized Bos taurus cytochrome c + H2O
-
 ?
reduced Bos taurus cytochrome c + O2 + H+
-
 Bos taurus oxidized Bos taurus cytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CCO
-
 Mus musculus
CCO
-
 Bos taurus
cytochrome c oxidase
-
 Mus musculus
cytochrome c oxidase
-
 Bos taurus