Literature summary for 7.1.1.9 extracted from

Katyare, S.S.; Patel, S.P.; Modi, H.R.
Diabetic modulation of the temperature kinetics properties of cytochrome oxidase activity in rat brain mitochondria (2008), Neurochem. Res., 33, 422-429.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Insulin	insulin treatment at early stage of diabetes (1-week diabetic animals) results in hyper-stimulation, but it is ineffective in restoring the activity in 1-month diabetic animals	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	enzyme activity decreases only at the late stage of diabetes which is not normalized by insulin treatment. Activity at room temperature (25°C) as well as at physiological temperature (37°C) is not affected by the diabetic state. At the late stage of diabetes the activity at 37°C decreases by 22%	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	adult male albino rats of Charles-Foster strain	-
Rattus norvegicus Charles-Foster	-	adult male albino rats of Charles-Foster strain	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,3,5,6-tetramethyl-p-phenylenediamine + O2	-	Rattus norvegicus	? + H2O	-	?
2,3,5,6-tetramethyl-p-phenylenediamine + O2	-	Rattus norvegicus Charles-Foster	? + H2O	-	?

Synonyms

Synonyms	Comment	Organism
cytochrome c oxidase	-	Rattus norvegicus

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Release 2023.1 (January 2023)