Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.1.1.9 extracted from

  • Jung, M.E.; Agarwal, R.; Simpkins, J.W.
    Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner (2007), Neurosci. Lett., 416, 160-164.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Application

Application Comment Organism
additional information counteracting relationship exists between the effects of withdrawal and 17beta-estradiol on the activity of COX in a subunit specific manner, which may not alter protein synthesis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information ethanol withdrawal decreases the activity of total COX, COX I, and COX IV. Estrogen treatment (17beta-estradiol) prevents the effects of withdrawal on the activities of total COX and COX IV but not COX I. Neither withdrawal nor 17beta-estradiol alter the protein levels of the subunits Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 young adult female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
additional information cortex Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
COX
-
 Rattus norvegicus
COX I
-
 Rattus norvegicus
COX IV
-
 Rattus norvegicus
cytochrome c oxidase
-
 Rattus norvegicus