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Literature summary for 7.1.1.9 extracted from

  • Huettemann, M.; Lee, I.; Kreipke, C.W.; Petrov, T.
    Suppression of the inducible form of nitric oxide synthase prior to traumatic brain injury improves cytochrome c oxidase activity and normalizes cellular energy levels (2008), Neuroscience, 151, 148-154.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine lack of energy after traumatic brain injury caused by inhibition of CcO may be an important aspect of trauma pathology Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
NO increased NO production after traumatic brain injury triggers inhibition of CcO. Traumatic brain injury leads to CcO inhibition and dramatically decreased ATP levels in brain cortex. CcO inhibition can be partially restored by application of iNOS antisense oligonucleotides prior to traumatic brain injury, which leads to a normalization of ATP levels similar to the controls Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
CCO
-
 Rattus norvegicus
cytochrome c oxidase
-
 Rattus norvegicus