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Literature summary for 7.1.1.9 extracted from
- Homocysteine restricts copper availability leading to suppression of cytochrome C oxidase activity in phenylephrine-treated cardiomyocytes (2013), PLoS ONE, 8, e67549 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | contains copper | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | Rattus norvegicus | - |
ferricytochrome c + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | - |
Rattus norvegicus | ferricytochrome c + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCO | - |
Rattus norvegicus |
| COX-IV | subunit | Rattus norvegicus |
| cytochrome c oxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | cardiomyocyte hypertrophy induced by phenylephrine is accompanied by suppression of cytochrome c oxidase activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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