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BRENDA support

Literature summary for 7.1.1.9 extracted from

  • Durand, A.; Bourbon, M.L.; Steunou, A.S.; Khalfaoui-Hassani, B.; Legrand, C.; Guitton, A.; Astier, C.; Ouchane, S.
    Biogenesis of the bacterial cbb3 cytochrome c oxidase Active subcomplexes support a sequential assembly model (2018), J. Biol. Chem., 293, 808-818 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rubrivivax gelatinosus Q5GCA8 and Q5GCA7 and Q5GCA5 and Q5GCA6 Q5GCA8 i.e. catalytic subunit CcoN, Q5GCA7 i.e. subunit CcoO, Q5GCA5 i.e. subunit CcoP, Q5GCA6 i.e. subunit CcoQ
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Synonyms

Synonyms Comment Organism
cbb3
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Rubrivivax gelatinosus

Expression

Organism Comment Expression
Rubrivivax gelatinosus cbb3-Cox activity and expression are maximal under microaerobiosis up

General Information

General Information Comment Organism
metabolism sequential assembly model of cbb3 cytochrome c oxidase. The CcoQ subunit is required for the early maturation step, CcoQ first associates with CcoN before the CcoNQ-CcoO interaction. CcoP associates to CcoNQO subcomplex in the late maturation step, and once the CcoNQOP complex is fully formed, CcoQ is released for degradation by the FtsH protease. Under microaerobiosis conditions, the wild-type strain reduces oxygen at a rate of 5.8% of dissolved oxygen/h. The O2 consumption rate is greatly and similarly affected in subunit mutants CcoN, CcoO and CcoP, but only reduced in a mutant lacking CcoQ Rubrivivax gelatinosus