Cloned (Comment) | Organism |
---|---|
transient overexpression of FOF1-ATP synthase alpha in human neuroblastoma SH-SY5Y cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Mus musculus | 31966 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | Mus musculus | - |
ADP + phosphate + H+/out | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | - |
Mus musculus | ADP + phosphate + H+/out | - |
r |
Subunits | Comment | Organism |
---|---|---|
multimer | FOF1-ATP synthase is a multi-subunit protein | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
ATP synthase | - |
Mus musculus |
F0F1-ATP synthase | - |
Mus musculus |
F0F1-ATP synthase alpha | - |
Mus musculus |
F0F1-ATPase | - |
Mus musculus |
More | the FOF1-ATP synthase alpha belongs to the family of stress proteins HSP60 | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | FOF1-ATP synthase plays a role in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease | Mus musculus |
physiological function | FOF1-ATP synthase synthesizes cellular ATP from ADP and inorganic phosphate. The FOF1-ATP synthase is localized in the mitochondria of eukaryotic cells, where it utilizes the electrochemical gradient, established across the inner mitochondrial membrane by oxidative phosphorylation, for the synthesis of ATP from ADP and inorganic phosphate. Recombinant ATP synthase alpha suppresses huntingtin aggregation when transiently overexpressed in SH-SY5Y cells, overview | Mus musculus |