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Literature summary for 7.1.2.2 extracted from

  • Rak, M.; McStay, G.P.; Fujikawa, M.; Yoshida, M.; Manfredi, G.; Tzagoloff, A.
    Turnover of ATP synthase subunits in F1-depleted HeLa and yeast cells (2011), FEBS Lett., 585, 2582-2586.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of Atp6p in HeLa cells depleted of the F1 beta subunit. Instead of being translationally downregulated, HeLa cells lacking F1 degrade Atp6p, thereby preventing proton leakage across the inner membrane Homo sapiens
expression of Atp6p in HeLa cells depleted of the F1 beta subunit. Instead of being translationally downregulated, HeLa cells lacking F1 degrade Atp6p, thereby preventing proton leakage across the inner membrane Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion mitochondrial translation of the Saccharomyces cerevisiae Atp6p subunit of F1-F0 ATP synthase is regulated by the F1 ATPase Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Homo sapiens
-
 ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in Saccharomyces cerevisiae
-
 ADP + phosphate + H+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Homo sapiens ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in
-
 Saccharomyces cerevisiae ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP synthase
-
 Homo sapiens
ATP synthase
-
 Saccharomyces cerevisiae
F1-F0 ATP synthase
-
 Homo sapiens
F1-F0 ATP synthase
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction expression of Atp6p in HeLa cells depleted of the F1 beta subunit. Instead of being translationally downregulated, HeLa cells lacking F1 degrade Atp6p, thereby preventing proton leakage across the inner membrane. Yeast mutants lacking beta subunit have stable aggregated F1 alpha subunit in the mitochondrial matrix Saccharomyces cerevisiae
malfunction HeLa cells lacking F1 degrade Saccharomyces cerevisiae Atp6p, thereby preventing proton leakage across the inner membrane. The human alpha subunit is completely degraded in cells deficient in F1 beta subunit. Depletion of the F1 beta subunit in the mutant shbeta-3 HeLa cell line elicits a remarkable decrease of alpha subunit. In MR6DATP1 lacking the F1 alpha subunit, the F1 beta subunit fails to assemble into the F1 oligomer and forms aggregates that resist solubilization by non-denaturing detergents such as lauryl maltoside Homo sapiens