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Literature summary for 7.1.2.2 extracted from

  • Gorai, T.; Goto, H.; Noda, T.; Watanabe, T.; Kozuka-Hata, H.; Oyama, M.; Takano, R.; Neumann, G.; Watanabe, S.; Kawaoka, Y.
    F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding (2012), Proc. Natl. Acad. Sci. USA, 109, 4615-4620.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of C-terminally c-Myc-tagged wild-type F1b eta or F1betaK212Q mutants in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K212Q site-directed mutagenesis for generation of mutation F1betaK212Q Homo sapiens
additional information siRNA-mediated downregulation of the beta subunit of the F1Fo-ATPase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane F1beta is present at the bottom ege of budding virions at the plasma membrane Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Homo sapiens
-
 ADP + phosphate + H+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Homo sapiens ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
F-type proton-translocating ATPase
-
 Homo sapiens
F1FO-ATPase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the siRNA-mediated downregulation of the beta subunit of the F1Fo-ATPase reduces influenza virion formation and virus growth in cell culture Homo sapiens
malfunction virion formation/Budding of Influenza virus particles is reduced in F1beta-depleted cells Homo sapiens
physiological function efficient influenza virion formation requires the ATPase activity of F1Fo-ATPase. Plasma membrane-associated, but not mitochondrial, F1Fo-ATPase, is important for influenza virion formation and budding, and release from cells Homo sapiens