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Literature summary for 7.2.1.1 extracted from

  • Muras, V.; Dogaru-Kinn, P.; Minato, Y.; Haese, C.C.; Steuber, J.
    The Na+-translocating NADH quinone oxidoreductase enhances oxidative stress in the cytoplasm of Vibrio cholerae (2016), J. Bacteriol., 198, 2307-2317 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Vibrio cholerae serotype O1 Q9KPS1 and Q9KPS2 and P0C6E0 and Q9X4Q6 and Q9X4Q7 and Q9X4Q8 Q9KPS1: subunit NqrA, Q9KPS2: subunit NqrB, P0C6E0: subunit NqrC, Q9X4Q6: subunit NqrD, Q9X4Q7: subunit NqrE, Q9X4Q8: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
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Vibrio cholerae serotype O1 ATCC 39315 Q9KPS1 and Q9KPS2 and P0C6E0 and Q9X4Q6 and Q9X4Q7 and Q9X4Q8 Q9KPS1: subunit NqrA, Q9KPS2: subunit NqrB, P0C6E0: subunit NqrC, Q9X4Q6: subunit NqrD, Q9X4Q7: subunit NqrE, Q9X4Q8: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
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Synonyms

Synonyms Comment Organism
Na-NQR
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 Vibrio cholerae serotype O1

Cofactor

Cofactor Comment Organism Structure
FAD the reduced FAD cofactor of cytoplasmic NqrF subunit is the site for intracellular superoxide formation Vibrio cholerae serotype O1

General Information

General Information Comment Organism
physiological function Na+-NQR acts as a as a producer of ROS in vivo. The amount of cytoplasmic ROS detected in Vibrio cholerae cells producing variants of Na+-NQR correlates well with rates of superoxide formation by the corresponding membrane fractions. Membranes from wild-type show increased superoxide production activity compared to membranes from a mutant lacking Na+-NQR. Overexpression of plasmid-encoded Na+-NQR results in a drastic increase in the formation of superoxide. The reduced FAD cofactor of cytoplasmic NqrF subunit is the site for intracellular superoxide formation Vibrio cholerae serotype O1