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Literature summary for 7.2.1.1 extracted from

  • Strickland, M.; Juarez, O.; Neehaul, Y.; Cook, D.A.; Barquera, B.; Hellwig, P.
    The conformational changes induced by ubiquinone binding in the Na+-pumping NADH ubiquinone oxidoreductase (Na+-NQR) are kinetically controlled by conserved glycines 140 and 141 of the NqrB subunit (2014), J. Biol. Chem., 289, 23723-23733 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Vibrio cholerae serotype O1

Protein Variants

Protein Variants Comment Organism
G140A mutation in subunit NrqB, affects ubiquinone reduction and the proper functioning of the sodium pump. Mutation does not not affect the dissociation constant of ubiquinone or inhibitor 2-n-heptyl-4-hydroxyquinoline N-oxide from Na+-NQR and prevents the conformational change involved in ubiquinone binding Vibrio cholerae serotype O1
G141V mutation in subunit NrqB, affects ubiquinone reduction and the proper functioning of the sodium pump. Mutation does not not affect the dissociation constant of ubiquinone or inhibitor 2-n-heptyl-4-hydroxyquinoline N-oxide from Na+-NQR and prevents the conformational change involved in ubiquinone binding Vibrio cholerae serotype O1

Inhibitors

Inhibitors Comment Organism Structure
2-n-heptyl-4-hydroxyquinoline N-oxide
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 Vibrio cholerae serotype O1

Organism

Organism UniProt Comment Textmining
Vibrio cholerae serotype O1 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
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Vibrio cholerae serotype O1 ATCC 39541 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the site of ubiquinone reduction is conformationally coupled to the NqrB subunit, which also hosts the final cofactor in the electron transport chain, riboflavin Vibrio cholerae serotype O1 ?
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 ?
additional information the site of ubiquinone reduction is conformationally coupled to the NqrB subunit, which also hosts the final cofactor in the electron transport chain, riboflavin Vibrio cholerae serotype O1 ATCC 39541 ?
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 ?