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Literature summary for 7.2.2.8 extracted from

  • Pilankatta, R.; Lewis, D.; Adams, C.M.; Inesi, G.
    High yield heterologous expression of wild-type and mutant Cu+-ATPase (ATP7B, Wilson disease protein) for functional characterization of catalytic activity and serine residues undergoing copper-dependent phosphorylation (2009), J. Biol. Chem., 284, 21307-21316.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C983A/C985A the mutant is less phosphorylated than the wild type enzyme Homo sapiens
D1027N the mutant is less phosphorylated than the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu+ the enzyme contains six copper binding sites Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu+[side 1] Homo sapiens
-
 ADP + phosphate + Cu+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu+[side 1]
-
 Homo sapiens ADP + phosphate + Cu+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ATP7B
-
 Homo sapiens
Wilson disease protein
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is required for copper homeostasis Homo sapiens