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Literature summary for 7.2.2.8 extracted from

  • Gonzalez-Guerrero, M.; Raimunda, D.; Cheng, X.; Argueello, J.M.
    Distinct functional roles of homologous Cu+ efflux ATPases in Pseudomonas aeruginosa (2010), Mol. Microbiol., 78, 1246-1258.
    View publication on PubMed
Search for more literature for 7.2.2.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DC194 cells Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Pseudomonas aeruginosa 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu+[side 1] Pseudomonas aeruginosa
-
 ADP + phosphate + Cu+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu+[side 1]
-
 Pseudomonas aeruginosa ADP + phosphate + Cu+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
CopA1 isoform Pseudomonas aeruginosa
CopA2 isoform Pseudomonas aeruginosa
Cu+-ATPase
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction mutation of isoform CopA2 has no effect on Cu toxicity nor intracellular Cu levels but it leads to higher H2O2 sensitivity and reduced cytochrome oxidase activity Pseudomonas aeruginosa
physiological function Isoforms CopA1 and CopA2 catalyse cytoplasmic Cu+ efflux into the periplasm. Isoforms CopA1 and CopA2 are essential for virulence. Isoform CopA1 maintains the cellular Cu quota and provides tolerance to this metal Pseudomonas aeruginosa