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Literature summary for 7.2.2.8 extracted from
- Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells (2013), Am. J. Physiol. Cell Physiol., 304, C257-C262.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression in rat intestinal epithelial IEC-6 cells, Atp7a protein expression is induced more strongly than mRNA in the duodenum of iron-deprived rats, real-time quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells. Copper has a direct influence on Atp7a protein expression independent of changes in mRNA levels | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q04656 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATP7A | - |
Homo sapiens |
| Menkes copper-transporting ATPase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | copper has a direct influence on Atp7a protein expression independent of changes in mRNA levels | additional information |
| Homo sapiens | Atp7a expression is upregulated by iron chelation and copper loading. Recombinant Atp7a protein expression is induced more strongly than mRNA in the duodenum of iron-deprived rats, Atp7a expression is upregulated by iron chelation and copper loading, iron chelation increases Atp7a mRNA expression by 1.6fold, but has little effect on protein levels | up |
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Release 2023.1 (January 2023)
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