Literature summary for 7.2.2.8 extracted from

Hilario-Souza, E.; Cuillel, M.; Mintz, E.; Charbonnier, P.; Vieyra, A.; Cassio, D.; Lowe, J.
Modulation of hepatic copper-ATPase activity by insulin and glucagon involves protein kinase A (PKA) signaling pathway (2016), Biochim. Biophys. Acta, 1862, 2086-2097 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Insulin	insulin reverses the effect of copper and stimulates retrograde trafficking of ATP7B from the canalicular membranes, consistent with the enhanced ability of ATP7B to sequester copper away from the cytosol. Physiological concentrations of insulin increase endogenous ATP7B activity in cultured hepatic cells and in tissues by 40%, whereas glucagon inhibits this activity by 70%. The opposite effects of the hormones on ATP7B activity involve receptor-mediated signaling pathways and membrane-bound kinases PKA and PKB/Akt	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
glucagon	physiological concentrations of insulin increase endogenous ATP7B activity in cultured hepatic cells and in tissues by 40%, whereas glucagon inhibits this activity by 70%. The opposite effects of the hormones on ATP7B activity involve receptor-mediated signaling pathways and membrane-bound kinases PKA and PKB/Akt	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35670	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
WIF-B9 cell	rat hepatoma/human fibroblast hybrid cell line	Homo sapiens	-

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Release 2023.1 (January 2023)