Literature summary for 7.2.2.8 extracted from

Comstra, H.; McArthy, J.; Rudin-Rush, S.; Hartwig, C.; Gokhale, A.; Zlatic, S.; Blackburn, J.; Werner, E.; Petris, M.; D'Souza, P.; Panuwet, P.; Barr, D.; Lupashin, V.; Vrailas-Mortimer, A.; Faundez, V.
The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors (2017), eLife, 6, e24722 .

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-
Homo sapiens	Q04656	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	-	Homo sapiens	-
SH-SY5Y cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ATP7A	-	Drosophila melanogaster
ATP7A	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	ATP7A interacts with hundreds of proteins present in different compartments within cells	Homo sapiens
physiological function	changes in the expression of ATP7A and conserved oligomeric Golgi subunits in Drosophila melanogaster neurons alter synapse development in larvae and copper-induced mortality of adult flies	Drosophila melanogaster
physiological function	conserved oligomeric Golgi (COG) null cells possess altered content and subcellular localization of ATP7A and CTR1 (SLC31A1), the transporter required for copper uptake, as well as decreased total cellular copper, and impaired copper-dependent metabolic responses	Homo sapiens

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Release 2023.1 (January 2023)