Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64430 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | A0A0H3NA56 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium SL1344 | A0A0H3NA56 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CopA | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
physiological function | deletion of the copper exporters, CopA and GolT decreases infection in wild-type mice but not in mice, in which the Atp7a transporter gen is specifically deleted in cells of the myeloid lineage | Salmonella enterica subsp. enterica serovar Typhimurium |
physiological function | in mice, in which the Atp7a gene is specifically deleted in cells of the myeloid lineage, including macrophages, primary macrophages isolated exhibit decreased copper transport into phagosomal compartments and a reduced ability to kill Salmonella enterica serovar Typhimurium compared to wild-type mice. The mutant mice are also more susceptible to systemic infection by Salmonella typhimurium than wild-type mice. Deletion of the Salmonella typhimurium copper exporters, CopA and GolT decreases infection in wild-type mice but not in the mutant mice | Mus musculus |