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Literature summary for 7.2.2.8 extracted from

  • Ladomersky, E.; Khan, A.; Shanbhag, V.; Cavet, J.; Chan, J.; Weisman, G.; Petris, M.
    Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection (2017), Infect. Immun., 85, e00351-17 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430
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Salmonella enterica subsp. enterica serovar Typhimurium A0A0H3NA56
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Salmonella enterica subsp. enterica serovar Typhimurium SL1344 A0A0H3NA56
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Synonyms

Synonyms Comment Organism
CopA
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Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
physiological function deletion of the copper exporters, CopA and GolT decreases infection in wild-type mice but not in mice, in which the Atp7a transporter gen is specifically deleted in cells of the myeloid lineage Salmonella enterica subsp. enterica serovar Typhimurium
physiological function in mice, in which the Atp7a gene is specifically deleted in cells of the myeloid lineage, including macrophages, primary macrophages isolated exhibit decreased copper transport into phagosomal compartments and a reduced ability to kill Salmonella enterica serovar Typhimurium compared to wild-type mice. The mutant mice are also more susceptible to systemic infection by Salmonella typhimurium than wild-type mice. Deletion of the Salmonella typhimurium copper exporters, CopA and GolT decreases infection in wild-type mice but not in the mutant mice Mus musculus