Literature summary for 7.2.2.8 extracted from

Wijekoon, C.J.; Udagedara, S.R.; Knorr, R.L.; Dimova, R.; Wedd, A.G.; Xiao, Z.
Copper ATPase CopA from Escherichia coli quantitative correlation between ATPase activity and vectorial copper transport (2017), J. Am. Chem. Soc., 139, 4266-4269 .

Search for more literature for 7.2.2.8

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
vanadate	0.2 mM, complete inhibition. Vanadate binds irreversibly to the P-domain phosphorylation site	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	inner membrane	Escherichia coli	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	enzyme binds Cu(I) witrh subfemtomolar affinity	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu+[side 1]	-	Escherichia coli	ADP + phosphate + Cu+[side 2]	-	?
additional information	in giant unilamellar vesicles, no Cu leakage or passive diffusion is found. The observed Cu uptake relies completely on active transportation	Escherichia coli	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 87900, SDS-PAGE	Escherichia coli

Synonyms

Synonyms	Comment	Organism
CopA	-	Escherichia coli

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Release 2023.1 (January 2023)