Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15431 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Ctr1 | - |
Homo sapiens |
SLC31A1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme specifically transports Cu(I) , but Ctr1 peptides bind Cu(II) at an amino terminal high-affinity Cu(II), Ni(II) (ATCUN) site. Ascorbate-dependent reduction of the Cu(II)-high-affinity Cu(II), Ni(II) (ATCUN) site is possible by virtue of an adjacent bis-His motif. Changes in the sequence proximity of the high-affinity site and bis-His motif lead to significant differences in coordination structure and chemical behavior | Homo sapiens |