Literature summary for 7.2.2.8 extracted from

Ponnandai Shanmugavel, K.; Petranovic, D.; Wittung-Stafshede, P.
Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast (2017), Metallomics, 9, 981-988 .

Search for more literature for 7.2.2.8

Application

Application	Comment	Organism
analysis	method to probe Cu flow through human Atox1 and copper chaperone ATP7B proteins when expressed in yeast.	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the presence of the most N-terminal metal-binding domain increases overall ATP7B-mediated Cu transport activity, whereas presence of the third metal-binding domain decreases the activity. Upon removal of all metal-binding domains in ATP7B, the ability to transport Cu disappears	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35670	-	-

Synonyms

Synonyms	Comment	Organism
ATP7B	-	Homo sapiens

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Release 2023.1 (January 2023)