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Literature summary for 7.2.4.2 extracted from
- Characterization of a membrane-bound biotin-containing enzyme: oxaloacetate decarboxylase from Klebsiella aerogenes (1981), Eur. J. Biochem., 115, 353-358.
General Stability
| General Stability | Organism |
|---|---|
| very instable, protease-sensitive, 50% loss of activity after 4 min at 4°C | Klebsiella aerogenes |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Oxomalonate | - |
Klebsiella aerogenes |  |
| citrate | not | Klebsiella aerogenes | |
| glyoxylate | - |
Klebsiella aerogenes | |
| L-malate | - |
Klebsiella aerogenes | |
| oxalate | Ki: 0.005 mM | Klebsiella aerogenes | |
| p-hydroxymercuribenzoate | 70% inhibition at 5 mM | Klebsiella aerogenes | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
oxaloacetate | - |
Klebsiella aerogenes | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Klebsiella aerogenes | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | Km: 0.78 mM | Klebsiella aerogenes | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oxaloacetate | Klebsiella aerogenes | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella aerogenes | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | transmembrane transport of Na+ | Klebsiella aerogenes | ? | - |
? | |
| Oxaloacetate | stereochemistry | Klebsiella aerogenes | Pyruvate + CO2 | - |
? | |
| oxaloacetate | - |
Klebsiella aerogenes | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | - |
Klebsiella aerogenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | - |
Klebsiella aerogenes | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | - |
oxalate | - |
Klebsiella aerogenes | |
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Release 2023.1 (January 2023)
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