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Literature summary for 7.4.2.1 extracted from

  • Risinger, A.L.; Cain, N.E.; Chen, E.J.; Kaiser, C.A.
    Activity-dependent reversible inactivation of the general amino acid permease (2006), Mol. Biol. Cell, 17, 4411-4419.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information Gap1p mutants, deficient in transport of a subset of amino acids, show that Gap1p inactivation at the plasma membrane does not depend on the presence of either extracellular or intracellular amino acids, but does require active amino acid transport by Gap1p Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
L-arginine 8% cell growth, 25% viability of cells Saccharomyces cerevisiae
L-asparagine 35% cell growth, 70% viability of cells Saccharomyces cerevisiae
L-citrulline 1% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-cysteine 1% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-glutamate 2% cell growth, 4% viability of cells Saccharomyces cerevisiae
L-glutamine 18% cell growth, 70% viability of cells Saccharomyces cerevisiae
L-Glycine 1% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-histidine 3% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-isoleucine 2% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-leucine 34% cell growth, 35% viability of cells Saccharomyces cerevisiae
L-lysine 1% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-methionine 16% cell growth, 70% viability of cells Saccharomyces cerevisiae
L-proline 9% cell growth, 701% viability of cells Saccharomyces cerevisiae
L-serine 20% cell growth, 25% viability of cells Saccharomyces cerevisiae
L-threonine 1% cell growth, 1% viability of cells Saccharomyces cerevisiae
L-tryptophan 4% cell growth, 25% viability of cells Saccharomyces cerevisiae
L-tyrosine 20% cell growth, 35% viability of cells Saccharomyces cerevisiae
L-valine 13% cell growth, 10% viability of cells Saccharomyces cerevisiae
additional information permease activity can be rapidly and reversibly inactivated by the presence of most amino acids, except alanine or phenylalanine, mixtures of amino acids are less toxic than single amino acids, the toxicity appears to be the consequence of uptake of unusually large quantities of a single amino acid Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Saccharomyces cerevisiae 5886
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Synonyms

Synonyms Comment Organism
Gap1p
-
Saccharomyces cerevisiae
general amino acid permease
-
Saccharomyces cerevisiae