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Literature summary for 7.6.2.2 extracted from

  • Jha, S.; Dabas, N.; Karnani, N.; Saini, P.; Prasad, R.
    ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry (2004), FEMS Yeast Res., 5, 63-72.
    View publication on PubMed
Search for more literature for 7.6.2.2

Application

Application Comment Organism
pharmacology Cdr1p is a critical factor in the design of therapeutic strategies to combat antifungal resistance Candida albicans

Cloned(Commentary)

Cloned (Comment) Organism
CDR1, overexpression in Saccharomyces cerevisiae AD1-8u- Candida albicans

Protein Variants

Protein Variants Comment Organism
C193K residue of the Walker A motif of the N-terminal nucleotide binding domain, mutant with 22% ATPase activity compared with native Cdr1p, mutant cells are not hypersensitive to drugs such as fluconazole, ansiomycin, miconazole or cycloheximide Candida albicans
C193K/K901 double mutant has an ATPase activity below 10% compared with native Cdr1p Candida albicans
K901C residue of the Walker A motif of the C-terminal nucleotide binding domain, mutant with 12% ATPase activity compared with native Cdr1p, mutant cells are hypersensitive to drugs such as fluconazole, ansiomycin, miconazole or cycloheximide and are unable to expel rhodamine 6G Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane transmembrane protein Candida albicans 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + azole/in Candida albicans the ABC multidrug transporter Cdr1p plays a key role in azole resistance ADP + phosphate + azole/out
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Organism

Organism UniProt Comment Textmining
Candida albicans
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + anisomycin/in recombinant Cdr1p Candida albicans ADP + phosphate + anisomycin/out
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 ?
ATP + H2O + azole/in the ABC multidrug transporter Cdr1p plays a key role in azole resistance Candida albicans ADP + phosphate + azole/out
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 ?
ATP + H2O + cycloheximide/in recombinant Cdr1p Candida albicans ADP + phosphate + cycloheximide/out
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 ?
ATP + H2O + fluconazole/in recombinant Cdr1p Candida albicans ADP + phosphate + fluconazole/out
-
 ?
ATP + H2O + miconazole/in recombinant Cdr1p Candida albicans ADP + phosphate + miconazole/out
-
 ?
ATP + H2O + rhodamine 6G/in recombinant Cdr1p Candida albicans ADP + phosphate + rhodamine 6G/out
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 ?
ATP + H2O + xenobiotic/in ABC multidrug transporter Cdr1p, domain structure, roles of Cys-193 of the Walker A motif of the N-terminal nucleotide binding domain and of Lys-901 of the Walker A motif of the C-terminal nucleotide binding domain in ATPase function, the two nucleotide binding domains influence the Cdr1p function asymmetrically Candida albicans ADP + phosphate + xenobiotic/out
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Synonyms

Synonyms Comment Organism
Cdr1p
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 Candida albicans