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Literature summary extracted from

  • Hoefer, R.; Dong, L.; Andre, F.; Ginglinger, J.F.; Lugan, R.; Gavira, C.; Grec, S.; Lang, G.; Memelink, J.; Van der Krol, S.; Bouwmeester, H.; Werck-Reichhart, D.
    Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway (2013), Metab. Eng., 20, 221-232 .
    View publication on PubMed


EC Number Cloned (Comment) Organism expression in Saccharomyces cerevisiae Catharanthus roseus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism homology modeling. The geraniol molecule is positioned close to protoporphyrin with the double bond C6-C7 parallel to the heme plane Catharanthus roseus


EC Number Organism UniProt Comment Textmining Catharanthus roseus Q8VWZ7

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac. geraniol + [reduced NADPH-hemoprotein reductase] + O2
Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
? additional information enzyme is a specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol. The first step, geraniol hydroxylation, is very efficient and fast enough to outcompete geraniol conjugation in plant tissues Catharanthus roseus ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure 2.8
geraniol pH 7.4, 27°C Catharanthus roseus

General Information

EC Number General Information Comment Organism physiological function transient expression in Nicotiana benthamiana leaf leads to formation of 8-hydroxygeraniol and 8-oxogeraniol Catharanthus roseus