Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Milazzo, L.; Gabler, T.; Pfanzagl, V.; Michlits, H.; Furtmueller, P.G.; Obinger, C.; Hofbauer, S.; Smulevich, G.
    The hydrogen bonding network of coproheme in coproheme decarboxylase from Listeria monocytogenes Effect on structure and catalysis (2019), J. Inorg. Biochem., 195, 61-70 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.3.98.5 K151A disruption of the H-bond interactions with p2 and p4, impairs the structural rearrangement upon binding of coproheme. Decarboxylation activity is highly impaired Listeria monocytogenes serotype 1/2a
1.3.98.5 Q187A catalytic activity similar to wild-type Listeria monocytogenes serotype 1/2a
1.3.98.5 R133A catalytic activity similar to wild-type Listeria monocytogenes serotype 1/2a
1.3.98.5 R179A catalytic activity similar to wild-type Listeria monocytogenes serotype 1/2a
1.3.98.5 Y113A catalytic activity similar to wild-type Listeria monocytogenes serotype 1/2a
1.3.98.5 Y113A/K151A disruption of the H-bond interactions with p2 and p4, impairs the structural rearrangement upon binding of coproheme Listeria monocytogenes serotype 1/2a
1.3.98.5 Y147A mutant is completely inactive Listeria monocytogenes serotype 1/2a
1.3.98.5 Y147A/R220A/S225A mutations affect the extended H-bond network spanning from p2 to p4 Listeria monocytogenes serotype 1/2a

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.5 Listeria monocytogenes serotype 1/2a Q8Y5F1
-
-
1.3.98.5 Listeria monocytogenes serotype 1/2a ATCC BAA-679 Q8Y5F1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.5 Fe-coproporphyrin III + 2 H2O2
-
Listeria monocytogenes serotype 1/2a heme b + 2 CO2 + 4 H2O
-
?
1.3.98.5 Fe-coproporphyrin III + 2 H2O2
-
Listeria monocytogenes serotype 1/2a ATCC BAA-679 heme b + 2 CO2 + 4 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.5 ChdC
-
Listeria monocytogenes serotype 1/2a