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Literature summary extracted from

  • Lobo, S.; Scott, A.; Videira, M.; Winpenny, D.; Gardner, M.; Palmer, M.; Schroeder, S.; Lawrence, A.; Parkinson, T.; Warren, M.; Saraiva, L.
    Staphylococcus aureus haem biosynthesis Characterisation of the enzymes involved in final steps of the pathway (2015), Mol. Microbiol., 97, 472-487 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.98.5 expression in Escherichia coli Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.5 Staphylococcus aureus A0A0S3DY11
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.5 Fe-coproporphyrin III + 2 H2O2
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Staphylococcus aureus protoheme + 2 CO2 + 4 H2O
-
?
1.3.98.5 additional information in the absence of H2O2, HemQ converts only around 1% of Fe-coproporphyrin III into protoheme IX Staphylococcus aureus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.5 HemQ
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Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.98.5 heme the presence of a heme cofactor bound to the enzyme does not seem to modify the biochemical and enzymatic properties of HemQ Staphylococcus aureus

General Information

EC Number General Information Comment Organism
1.3.98.5 physiological function enzymes HemY, HemH and HemQ act as a coproporphyrinogen III oxidase, coproporphyrin III ferrochelatase and Fe-coproporphyrin III oxidase/dehydrogenase Staphylococcus aureus