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Literature summary extracted from

  • Oosthuizen, C.; Gasa, N.; Hamilton, C.; Lall, N.
    Inhibition of mycothione disulphide reductase and mycobacterial biofilm by selected South African plants (2019), South Afr. J. Bot., 120, 291-297 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.15 additional information plant extracts from Alectra sessiliflora, Aloe plicatilis, Eucomis humilis, Eucomis vandermerwei, Euphorbia tirrucalli, Faurea saligna, Merwillia plumbea, Salvia africana-lutea, Sphedamnocarpus pruriens, Tarchonanthus camphorates, Typha capensis, Typha minima, and Withania somnifera show inhibitory activities against the enzyme exhibiting IC50 values of 0.1678, 0.9934, 0.3206, 0.1347, 0.2391, 0.042, 0.2361, 0.1023, 0.0615, 0.1329, 0.0538, 0.0479, and 0.1624 mg/ml, respectively Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.15 mycothione + NADPH + H+ Mycobacterium tuberculosis
-
 2 mycothiol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.15 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.15 mycothione + NADPH + H+
-
 Mycobacterium tuberculosis 2 mycothiol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.15 MTR
-
 Mycobacterium tuberculosis
1.8.1.15 mycothione disulphide reductase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.15 NADPH
-
 Mycobacterium tuberculosis