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Literature summary extracted from

  • Thompson, W.; Dawson, R.M.C.
    The triphosphoinositide phosphodiesterase of brain tissue (1964), Biochem. J., 91, 237-243.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 histone activates Bos taurus
3.1.4.11 protamine activates Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 CuCl2 0.1 mM, 53% inhibition Bos taurus
3.1.4.11 Cys 5 mM, 58% inhibition Bos taurus
3.1.4.11 diethyl ether 25% v/v, 22% inhibition Bos taurus
3.1.4.11 EDTA
-
 Bos taurus
3.1.4.11 Hg2+ 0.1 mM, 90% inhibition Bos taurus
3.1.4.11 NEM 5 mM, 34% inhibition Bos taurus
3.1.4.11 PCMB 0.5 mM, 78% inhibition Bos taurus
3.1.4.11 Phenylmercuriacetate 0.1 mM, 85% inhibition Bos taurus
3.1.4.11 reduced glutathione 6.8 mM, 35% inhibition Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ activates Bos taurus
3.1.4.11 Mg2+ activates Bos taurus
3.1.4.11 additional information no absolute requirement Bos taurus
3.1.4.11 NaCl marked activation in presence of lecithin or phosphatidylethanolamine Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?