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Literature summary extracted from

  • Orellana, O.; Jedlicki, E.; Allende, C.C.; Allende, J.E.
    Properties of a cyclic nucleotide phosphodiesterase of amphibian oocytes that is activated by calmodulin and calcium, by tryptic proteolysis, and by phospholipids (1984), Arch. Biochem. Biophys., 231, 345-354.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.17 lysophosphatidylcholine stimulation Xenopus laevis
3.1.4.17 lysophosphatidylethanolamine stimulation Xenopus laevis
3.1.4.17 phosphatidylinositol stimulation Xenopus laevis
3.1.4.17 stearate stimulation Xenopus laevis
3.1.4.17 Subtilisin stimulation, slightly more effective than trypsin Xenopus laevis
3.1.4.17 Trypsin activation Xenopus laevis

General Stability

EC Number General Stability Organism
3.1.4.17 50% glycerol stabilizes Xenopus laevis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 cortisol
-
 Xenopus laevis
3.1.4.17 linoleic acid
-
 Xenopus laevis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.005
-
 3',5'-cGMP
-
 Xenopus laevis
3.1.4.17 0.03
-
 3',5'-cAMP
-
 Xenopus laevis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.17 Ca2+ Ca2+/calmodulin stimulated Xenopus laevis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.17 66000
-
 SDS-PAGE Xenopus laevis
3.1.4.17 140000
-
 gel filtration Xenopus laevis

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17 2000fold Xenopus laevis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 oocyte
-
 Xenopus laevis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.17 additional information
-
-
 Xenopus laevis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Xenopus laevis 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Xenopus laevis 5'-GMP
-
 ?
3.1.4.17 nucleoside 3',5'-cyclic phosphate + H2O
-
 Xenopus laevis nucleoside 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.17 monomer 1 * 66000, SDS-PAGE Xenopus laevis
3.1.4.17 oligomer SDS-PAGE Xenopus laevis
3.1.4.17 oligomer x * 66000 Xenopus laevis