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Literature summary extracted from

  • Nakamura, J.; Lou, L.
    Biochemical characterization of human GMP synthetase (1995), J. Biol. Chem., 270, 7347-7353.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.3.5.2 synthesis importance of guanine synthesis in immune cell function, GMP synthetase is a potential target for immunosuppressive therapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.2 2-chloroadenosine
-
 Homo sapiens
6.3.5.2 3'-dAMP
-
 Homo sapiens
6.3.5.2 5'-deoxyadenosine
-
 Homo sapiens
6.3.5.2 6-Amino-9-D-psicofuranosylpurine
-
 Homo sapiens
6.3.5.2 AMP poor product inhibitor, competitive towards ATP Homo sapiens
6.3.5.2 ATPgammaS
-
 Homo sapiens
6.3.5.2 beta,gamma-Imidoadenosine 5-triphosphate
-
 Homo sapiens
6.3.5.2 Decoyinine uncompetitive towards Gln and XMP and noncompetitive towards ATP Homo sapiens
6.3.5.2 diphosphate
-
 Homo sapiens
6.3.5.2 glutamic acid-gamma-methyl ester competitive towards Gln Homo sapiens
6.3.5.2 GMP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.5.2 0.132
-
 ATP
-
 Homo sapiens
6.3.5.2 0.406
-
 Gln
-
 Homo sapiens
6.3.5.2 5.1
-
 NH4+
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.5.2 Mg2+ depends on MgATP2-, but additionally requires free Mg2+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.2 ATP + XMP + Gln
-
 Homo sapiens AMP + diphosphate + GMP + Glu
-
 ?
6.3.5.2 ATP + XMP + NH4+
-
 Homo sapiens AMP + diphosphate + GMP
-
 ?
6.3.5.2 ATPgammaS + XMP + Gln GMP formation is 10% that of ATP Homo sapiens ?
-
 ?
6.3.5.2 additional information glutaminase activity Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.5.2 additional information
-
 additional information
-
 Homo sapiens