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Literature summary extracted from

  • Cerdan, S.; Lusty, C.J.; Davis, K.N.; Jacobson, J.A.; Williamson, J.R.
    Role of calcium as an inhibitor of rat liver carbamylphosphate synthetase I (1984), J. Biol. Chem., 259, 323-331.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.16 Ca2+ the inhibitory effect of free Ca2+ is weak. The calcium inhibition can be accounted for primarily by competitive interaction of CaATP2- at the second MgATP2- binding site. With 1 mM free Mg2+ and 5 mM MgATP2-, half-maximal inhibition is obtained with 0.2 mM CaATP2- Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.16 1
-
 ATP
-
 Rattus norvegicus
6.3.4.16 1.35
-
 ATP
-
 Rattus norvegicus
6.3.4.16 2.2
-
 ATP
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.16 Co2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for CoATP2-: 2.2 mM Rattus norvegicus
6.3.4.16 Mg2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MgATP2-: 1.35 mM Rattus norvegicus
6.3.4.16 Mn2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MnATP2-: 1.0 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.16 2 ATP + NH4+ + HCO3- ATP in form of MnATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.4.16 2 ATP + NH4+ + HCO3- ATP in form of MgATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.4.16 2 ATP + NH4+ + HCO3- ATP in form of CoATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Rattus norvegicus ADP + phosphate + carbamoylphosphate
-
 ?