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Literature summary extracted from

  • Suzuke, O.; Kumazawa, T.; Seno, H.; Matsumoto, T.
    Acetylspermidine deacetylase activities in human organs (1987), Med. Sci. Res., 15, 675-676.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.48 2-mercaptoethanol slight inhibition at 1 mM Homo sapiens
3.5.1.48 8-hydroxyquinoline slight inhibition at 1 mM Homo sapiens
3.5.1.48 Acriflavin strong inhibition at 1 mM Homo sapiens
3.5.1.48 Cu2+ nearly complete inhibition at 1 mM Homo sapiens
3.5.1.48 dithiothreitol remarkable inhibition at 1 mM Homo sapiens
3.5.1.48 Fe2+ strong inhibition at 1 mM Homo sapiens
3.5.1.48 iodoacetamide slight inhibition at 1 mM Homo sapiens
3.5.1.48 NaN3 slight inhibition at 1 mM Homo sapiens
3.5.1.48 p-chloromercuribenzoic acid complete inhibition at 1 mM Homo sapiens
3.5.1.48 Pargyline slight inhibition at 1 mM Homo sapiens
3.5.1.48 Quinacrine strong inhibition at 1 mM Homo sapiens
3.5.1.48 Semicarbazide slight inhibition at 1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.48 0.211
-
N8-Acetylspermidine
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.48 brain lowest activity level Homo sapiens
-
3.5.1.48 heart
-
Homo sapiens
-
3.5.1.48 kidney
-
Homo sapiens
-
3.5.1.48 liver highest activity level Homo sapiens
-
3.5.1.48 lung
-
Homo sapiens
-
3.5.1.48 pancreas
-
Homo sapiens
-
3.5.1.48 small intestine
-
Homo sapiens
-
3.5.1.48 spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.48 diacetylspermidine + H2O 81.9% activity of that of N8-acetylspermidine Homo sapiens acetate + spermidine
-
?
3.5.1.48 N1-acetylspermidine + H2O low activity Homo sapiens acetate + spermidine
-
?
3.5.1.48 N8-acetylspermidine + H2O highest activity Homo sapiens acetate + spermidine
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.48 8 8.5
-
Homo sapiens