EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.3 | medicine | - |
Gallus sp. |
2.1.2.3 | medicine | target for development of inhibitors with potential use as chemotherapeutic agents | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Gallus sp. | |
2.1.2.3 | 4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Homo sapiens | |
2.1.2.3 | KCl | - |
Homo sapiens | |
3.5.4.10 | 2'-deoxy-AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | 2-fluoroadenine arabinoside 5'-monophosphate | IC50-value in cell culture 0.0002 mM; strong competitive inhibitor, derivative of anti-cancer drug | Homo sapiens | |
3.5.4.10 | 2-mercaptoinosine 5'-monophosphate | most potent competitive inhibitor, precursor of GMP in the purine pathway | Homo sapiens | |
3.5.4.10 | 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | 6-mercaptopurine riboside 5'-monophosphate | IC50-value in cell culture 0.0075 mM; strong competitive inhibitor, derivative of anti-cancer drug | Homo sapiens | |
3.5.4.10 | adenosine N1-oxide 5'-monophosphate | IC50-value in cell culture 0.0011 microM; strong competitive inhibitor | Homo sapiens | |
3.5.4.10 | AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | GMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | IMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | N-succino-AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | N2-acetyl-2'deoxyguanosine 5'-monophosphate | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
3.5.4.10 | N6-(carboxymethyl)adenosine 5'-monophosphate | strong competitive inhibitor | Homo sapiens | |
3.5.4.10 | xanthosine 5'-monophosphate | strong competitive inhibitor | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.2.3 | 64400 | - |
2 * 64400, deduced from nucleotide sequence of cDNA | Homo sapiens |
3.5.4.10 | 62100 | - |
2 * 62100, protein mobility assay | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Bacillus subtilis | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Escherichia coli | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | de novo synthesis of purine nucleotides | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | de novo synthesis of purine nucleotides | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
3.5.4.10 | 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | Homo sapiens | de novo purine synthesis step 10 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Bacillus subtilis | - |
- |
- |
2.1.2.3 | Escherichia coli | - |
- |
- |
2.1.2.3 | Gallus sp. | - |
chicken | - |
2.1.2.3 | Gallus sp. | - |
avian | - |
2.1.2.3 | Homo sapiens | - |
human | - |
3.5.4.10 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.3 | - |
Homo sapiens |
3.5.4.10 | 780fold to apparent homogeneity | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.3 | CCRF-CEM cell | leukemia cell, T lymphoblastoid cell line | Homo sapiens | - |
2.1.2.3 | liver | - |
Homo sapiens | - |
2.1.2.3 | liver | - |
Gallus sp. | - |
2.1.2.3 | MCF-7 cell | breast cancer cell | Homo sapiens | - |
3.5.4.10 | CEM cell | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.2.3 | 0.00067 | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Bacillus subtilis | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Escherichia coli | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | de novo synthesis of purine nucleotides | Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | de novo synthesis of purine nucleotides | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Bacillus subtilis | ? | - |
? | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Escherichia coli | ? | - |
? | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Bacillus subtilis | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Escherichia coli | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
3.5.4.10 | 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | de novo purine synthesis step 10 | Homo sapiens | ? | - |
? | |
3.5.4.10 | 5-formamidoimidazole-4-carboxamide | - |
Homo sapiens | hypoxanthine + H2O | - |
ir |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.3 | dimer | - |
Gallus sp. |
2.1.2.3 | dimer | 2 * 64400, deduced from nucleotide sequence of cDNA | Homo sapiens |
3.5.4.10 | dimer | 2 * 62100, protein mobility assay | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase | bifunctional enzyme | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.4.10 | 37 | - |
- |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.4.10 | 7.4 | - |
- |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.4.10 | 0.0000011 | - |
IC50-value in cell culture 0.0011 microM | Homo sapiens | adenosine N1-oxide 5'-monophosphate | |
3.5.4.10 | 0.0002 | - |
IC50-value in cell culture 0.0002 mM | Homo sapiens | 2-fluoroadenine arabinoside 5'-monophosphate | |
3.5.4.10 | 0.0075 | - |
IC50-value in cell culture 0.0075 mM | Homo sapiens | 6-mercaptopurine riboside 5'-monophosphate |