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Literature summary extracted from
- Amino acid racemases and epimerases (1972), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 6, 479-507.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.3 | additional information | - |
Limosilactobacillus fermentum | |
| 5.1.1.3 | additional information | not stimulated by the addition of pyridoxal 5'-phosphate | Lactiplantibacillus plantarum | |
| 5.1.1.7 | additional information | no pyridoxal phosphate requirement | Escherichia coli | |
| 5.1.1.7 | additional information | no pyridoxal phosphate requirement | Priestia megaterium |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 5.1.1.9 | - |
Pseudomonas graveolens |
| 5.1.1.10 | - |
Pseudomonas putida |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.3 | FAD | and analogs | Limosilactobacillus fermentum |  |
| 5.1.1.3 | FMN | - |
Limosilactobacillus fermentum | |
| 5.1.1.3 | hydroxylamine | - |
Lactiplantibacillus plantarum | |
| 5.1.1.3 | hydroxylamine | different experimentators found inhibition or no inhibition | Limosilactobacillus fermentum | |
| 5.1.1.3 | riboflavin | slight inhibition, restoration by FAD | Limosilactobacillus fermentum | |
| 5.1.1.7 | hydroxylamine | no inhibition | Escherichia coli | |
| 5.1.1.7 | hydroxylamine | no inhibition | Priestia megaterium | |
| 5.1.1.7 | isoniazid | - |
Escherichia coli | |
| 5.1.1.7 | Mercurials | - |
Escherichia coli | |
| 5.1.1.7 | additional information | - |
Escherichia coli | |
| 5.1.1.7 | additional information | no inhibition by deoxypyridioxine | Priestia megaterium | |
| 5.1.1.7 | Semicarbazide | - |
Escherichia coli | |
| 5.1.1.7 | Semicarbazide | no inhibition | Priestia megaterium | |
| 5.1.1.11 | cyanide | - |
Brevibacillus brevis | |
| 5.1.1.11 | hydroxylamine | - |
Brevibacillus brevis | |
| 5.1.1.11 | isoniazid | - |
Brevibacillus brevis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.7 | 6.7 | - |
LL-diaminoheptanedioate | at 37°C | Priestia megaterium | |
| 5.1.1.7 | 100 | - |
meso-diaminoheptanedioate | at 37°C | Priestia megaterium | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.3 | 23000 | - |
gel filtration | Limosilactobacillus fermentum |
| 5.1.1.8 | 64000 | - |
- |
Pseudomonas putida |
| 5.1.1.10 | 110000 | - |
- |
Pseudomonas putida |
| 5.1.1.11 | 100000 | - |
sucrose density gradient centrifugation | Brevibacillus brevis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.2 | Pseudomonas sp. | - |
- |
- |
| 5.1.1.3 | Lactiplantibacillus plantarum | - |
- |
- |
| 5.1.1.3 | Limosilactobacillus fermentum | - |
- |
- |
| 5.1.1.7 | Escherichia coli | - |
- |
- |
| 5.1.1.7 | Priestia megaterium | - |
- |
- |
| 5.1.1.8 | Pseudomonas putida | - |
- |
- |
| 5.1.1.9 | Pseudomonas graveolens | - |
- |
- |
| 5.1.1.10 | Pseudomonas putida | - |
- |
- |
| 5.1.1.11 | Brevibacillus brevis | - |
- |
- |
| 5.1.1.13 | Limosilactobacillus fermentum | - |
- |
- |
| 5.1.1.13 | Pseudomonas sp. | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.1.1.3 | - |
Lactiplantibacillus plantarum |
| 5.1.1.3 | - |
Limosilactobacillus fermentum |
| 5.1.1.7 | - |
Priestia megaterium |
| 5.1.1.8 | - |
Pseudomonas putida |
| 5.1.1.9 | - |
Pseudomonas graveolens |
| 5.1.1.10 | - |
Pseudomonas putida |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.2 | L-Methionine | - |
Pseudomonas sp. | D-Methionine | - |
? | |
| 5.1.1.3 | D-Glu | - |
Lactiplantibacillus plantarum | L-Glu | - |
? | |
| 5.1.1.3 | D-Glu | - |
Limosilactobacillus fermentum | L-Glu | - |
? | |
| 5.1.1.7 | LL-2,6-Diaminoheptanedioate | - |
Escherichia coli | meso-Diaminoheptanedioate | - |
? | |
| 5.1.1.7 | LL-2,6-Diaminoheptanedioate | - |
Priestia megaterium | meso-Diaminoheptanedioate | - |
? | |
| 5.1.1.8 | trans-4-hydroxy-L-Pro | - |
Pseudomonas putida | cis-4-hydroxy-D-Pro | - |
? | |
| 5.1.1.11 | ATP + L-Phe + H2O | - |
Brevibacillus brevis | AMP + diphosphate + D-Phe | - |
? | |
| 5.1.1.13 | L-Asp | - |
Pseudomonas sp. | D-Asp | - |
? | |
| 5.1.1.13 | L-Asp | - |
Limosilactobacillus fermentum | D-Asp | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.7 | 6.5 | 8 | - |
Priestia megaterium |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.7 | 6 | 8.5 | pH 6: about 60% of maximal activity, pH 8.5: about 25% of maximal activity | Priestia megaterium |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.2 | pyridoxal 5'-phosphate | required | Pseudomonas sp. | |
| 5.1.1.9 | pyridoxal 5'-phosphate | contains 4 mol of pyridoxal 5'-phosphate per mol of enzyme | Pseudomonas graveolens | |
| 5.1.1.10 | pyridoxal 5'-phosphate | pyridoxal phosphate enzyme | Pseudomonas putida | |
| 5.1.1.10 | pyridoxal 5'-phosphate | holoenzyme contains 2 mol of pyridoxal 5'-phosphate per mol of enzyme | Pseudomonas putida | |
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