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Literature summary extracted from

  • Ray, M.; Ray, S.
    Purification and partial characterization of a methylglyoxal reductase from goat liver (1984), Biochim. Biophys. Acta, 802, 119-127.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.78 5,5'-dithiobis(2-nitrobenzoate)
-
 Capra hircus
1.1.1.78 p-chloromercuribenzoate
-
 Capra hircus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.78 0.2
-
 NADH
-
 Capra hircus
1.1.1.78 0.3
-
 Phenylglyoxal
-
 Capra hircus
1.1.1.78 0.4
-
 methylglyoxal
-
 Capra hircus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.78 cytosol
-
 Capra hircus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.78 46000
-
 2 * 46000, SDS-PAGE Capra hircus
1.1.1.78 89000
-
 gel filtration Capra hircus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.78 methylglyoxal + NADH Capra hircus
-
 (R)-lactaldehyde + NAD+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.78 Capra hircus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.78 liver
-
 Capra hircus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.78 69.2
-
-
 Capra hircus

Storage Stability

EC Number Storage Stability Organism
1.1.1.78 4°C, 15 days Capra hircus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.78 acetaldehyde + NADH + H+
-
 Capra hircus ethanol + NAD+
-
 ?
1.1.1.78 glyceraldehyde + NADH
-
 Capra hircus glycerol + NAD+
-
 ?
1.1.1.78 methylglyoxal + NADH
-
 Capra hircus (R)-lactaldehyde + NAD+
-
 ir
1.1.1.78 additional information NADH better substrate than NADPH Capra hircus ?
-
 ?
1.1.1.78 phenylglyoxal + NADH
-
 Capra hircus hydroxyphenylacetaldehyde + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.78 dimer 2 * 46000, SDS-PAGE Capra hircus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.78 6.5
-
 reduction of methylglyoxal Capra hircus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.78 NADH NADH better substrate than NADPH Capra hircus
1.1.1.78 NADPH NADH better substrate than NADPH Capra hircus