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Literature summary extracted from

  • Katz, E.; Brown, D.; Hitchcock, M.J.M.
    Arylformamidase from Streptomyces parvulus (1987), Methods Enzymol., 142, 225-234.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.9 Ag+ complete inhibition at 0.01 mM Streptomyces parvulus
3.5.1.9 arsenate strong inhibition for formamidase I, slight inhibition for formamidase II at 1 mM Streptomyces parvulus
3.5.1.9 Cu2+ complete inhibition at 1 mM Streptomyces parvulus
3.5.1.9 Fe2+ 31% inhibition only for formamidase II at 1 mM Streptomyces parvulus
3.5.1.9 Hg2+ complete inhibition at 1 mM Streptomyces parvulus
3.5.1.9 hydrosulfite strong inhibition at 1 mM Streptomyces parvulus
3.5.1.9 Na-bisulfite strong inhibition 10 mM Streptomyces parvulus
3.5.1.9 NaF at 10 mM: strong inhibition for formamidase I, slight inhibition for formamidase II Streptomyces parvulus
3.5.1.9 NaHSO3 strong inhibition at at 10 mM Streptomyces parvulus
3.5.1.9 p-hydroxymercuribenzoate complete inhibition at 1 mM Streptomyces parvulus
3.5.1.9 phenylmethylsulfonyl fluoride strong inhibition Streptomyces parvulus
3.5.1.9 Zn2+ complete inhibition of formamidase I at 1 mM, 88% inhibition of formamidase II at 1 mM Streptomyces parvulus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.9 0.31
-
N-formyl-L-kynurenine formamidase II Streptomyces parvulus
3.5.1.9 0.34
-
N-formyl-L-kynurenine formamidase I Streptomyces parvulus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.9 intracellular
-
Streptomyces parvulus 5622
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.9 27000
-
formamidase II, gel filtration Streptomyces parvulus
3.5.1.9 43000
-
formamidase I, gel filtration Streptomyces parvulus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O Streptomyces parvulus preferred substrate, involved in formation of antibiotics and NAD+ L-kynurenine + formate
-
?
3.5.1.9 N-formyl-o-aminoacetophenone + H2O Streptomyces parvulus low activity for both formamidases I and II formate + o-aminoacetophenone
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.9 Streptomyces parvulus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.9 to homogeneity, chromatography techniques, 2 forms Streptomyces parvulus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.9 mycelium 2 forms: formamidase I, formamidase II Streptomyces parvulus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.9 8.33
-
formamidase I Streptomyces parvulus
3.5.1.9 26.8
-
formamidase II Streptomyces parvulus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O preferred substrate, involved in formation of antibiotics and NAD+ Streptomyces parvulus L-kynurenine + formate
-
?
3.5.1.9 N-formyl-o-aminoacetophenone + H2O low activity for both formamidases I and II Streptomyces parvulus formate + o-aminoacetophenone
-
?
3.5.1.9 N1,Nalpha-diformyl-L-kynurenine + H2O lower activity for formamidases I and II than for its natural substrate Streptomyces parvulus formate + N-alpha-L-kynurenine
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.9 30
-
formamidase II Streptomyces parvulus
3.5.1.9 50
-
formamidase I Streptomyces parvulus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.1.9 30
-
activity of formamidase II declines sharp at higher temperatures Streptomyces parvulus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.9 7 8 formamidase I Streptomyces parvulus
3.5.1.9 7
-
formamidase II Streptomyces parvulus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.9 0.32
-
Na-bisulfite
-
Streptomyces parvulus