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Literature summary extracted from

  • Kim, C.J.; Kimm, S.W.
    Enzymatic evidence for a mitochondrial inhibitor of guanine aminohydrolase in rat liver (1982), Korean J. Biochem., 14, 77-93.
No PubMed abstract available

General Stability

EC Number General Stability Organism
3.5.4.3 stable to heat Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 5-aminoimidazole-4-carboxamide
-
 Homo sapiens
3.5.4.3 5-aminoimidazole-4-carboxamide
-
 Rattus norvegicus
3.5.4.3 Ag+ 6.5% inhibition at 2 mM Rattus norvegicus
3.5.4.3 Fe3+
-
 Rattus norvegicus
3.5.4.3 Hg2+ 98.6% inhibition at 2 mM Rattus norvegicus
3.5.4.3 Li+
-
 Rattus norvegicus
3.5.4.3 natural inhibitor protein
-
 Homo sapiens
3.5.4.3 natural inhibitor protein
-
 Mus musculus
3.5.4.3 natural inhibitor protein heat labile proteinous mitochondrial inhibitor for liver and brain enzyme Rattus norvegicus
3.5.4.3 Pb2+ 55.5% inhibition at 2 mM Rattus norvegicus
3.5.4.3 Zn2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Mus musculus
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Homo sapiens
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Rattus norvegicus
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Ophiodon elongatus
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Clostridium sp.
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Rattus norvegicus Sprague Dawley
-
 xanthine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Clostridium sp.
-
 C. acidiurici
-
3.5.4.3 Homo sapiens
-
 human
-
3.5.4.3 Mus musculus
-
 mouse
-
3.5.4.3 Ophiodon elongatus
-
 lingcod
-
3.5.4.3 Rattus norvegicus
-
 Sprague Dawley strain
-
3.5.4.3 Rattus norvegicus Sprague Dawley
-
 Sprague Dawley strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.3
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 brain
-
 Mus musculus
-
3.5.4.3 brain
-
 Homo sapiens
-
3.5.4.3 brain
-
 Rattus norvegicus
-
3.5.4.3 kidney
-
 Homo sapiens
-
3.5.4.3 kidney
-
 Rattus norvegicus
-
3.5.4.3 liver
-
 Mus musculus
-
3.5.4.3 liver
-
 Homo sapiens
-
3.5.4.3 liver
-
 Rattus norvegicus
-
3.5.4.3 lung
-
 Homo sapiens
-
3.5.4.3 lung
-
 Rattus norvegicus
-
3.5.4.3 muscle
-
 Homo sapiens
-
3.5.4.3 muscle
-
 Ophiodon elongatus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.3 1.14
-
 purified liver enzyme Rattus norvegicus
3.5.4.3 1.36
-
 kidney enzyme Rattus norvegicus
3.5.4.3 9.9
-
 liver enzyme, isoenzyme A Rattus norvegicus
3.5.4.3 13.2
-
 brain enzyme Rattus norvegicus
3.5.4.3 23.5
-
 lung enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
 Mus musculus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Homo sapiens xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Rattus norvegicus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Ophiodon elongatus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Clostridium sp. xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Rattus norvegicus Sprague Dawley xanthine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.3 dimer
-
 Homo sapiens
3.5.4.3 dimer
-
 Rattus norvegicus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.4.3
-
 80
-
 Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.3 70
-
 activity remains unaffected from 0-50°C, 19.3% inactivation at 60°C, 33% inactivation at 70°C, complete lost of activity at 80°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.3 7.5
-
-
 Rattus norvegicus