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Literature summary extracted from

  • Fogle, P.J.; Bieber, A.L.
    Purification of rabbit liver guanine aminohydrolase (1975), Prep. Biochem., 5, 59-77.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Homo sapiens
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Oryctolagus cuniculus
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Rattus norvegicus
3.5.4.3 9-(p-aminoethoxyphenyl)guanine strong inhibitor Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.3 0.0056
-
guanine
-
Homo sapiens
3.5.4.3 0.0056
-
guanine at pH 8 Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.3 26000
-
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 49000
-
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 77000
-
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 100000
-
gel filtration, different molecular weight polymers of the enzyme Homo sapiens
3.5.4.3 100000
-
gel filtration, different molecular weight polymers of the enzyme Oryctolagus cuniculus
3.5.4.3 117000
-
gel filtration, lower pH and lower ionic strength, 2 different polymers Oryctolagus cuniculus
3.5.4.3 207000
-
2 forms of liver enzyme Oryctolagus cuniculus
3.5.4.3 265000
-
gel filtration, lower pH and lower ionic strength, 2 different polymers Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Homo sapiens
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Rattus norvegicus
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Ophiodon elongatus
-
xanthine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Homo sapiens
-
human
-
3.5.4.3 Ophiodon elongatus
-
lingcod
-
3.5.4.3 Oryctolagus cuniculus
-
rabbit
-
3.5.4.3 Rattus norvegicus
-
rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.3
-
Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 brain
-
Homo sapiens
-
3.5.4.3 brain
-
Rattus norvegicus
-
3.5.4.3 brain
-
Oryctolagus cuniculus
-
3.5.4.3 liver
-
Homo sapiens
-
3.5.4.3 liver
-
Rattus norvegicus
-
3.5.4.3 liver
-
Oryctolagus cuniculus
-
3.5.4.3 muscle
-
Homo sapiens
-
3.5.4.3 muscle
-
Ophiodon elongatus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.3 12.6
-
-
Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
Homo sapiens xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Rattus norvegicus xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Ophiodon elongatus xanthine + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.3 oligomer 1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.3 8
-
-
Homo sapiens
3.5.4.3 8
-
-
Rattus norvegicus
3.5.4.3 8
-
-
Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.3 5.6 9.5
-
Oryctolagus cuniculus