Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cacciamani, T.; Vita, A.; Cristalli, G.; Vincenzetti, S.; Natalini, P.; Ruggieri, S.; Amici, A.; Magni, G.
    Purification of human cytidine deaminase: Molecular and enzymatic characterization and inhibition by synthetic pyrimidine analogs (1991), Arch. Biochem. Biophys., 290, 285-292.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.5 medicine enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.5 2'-deoxyuridine
-
Homo sapiens
3.5.4.5 2-thio-6-azarudine
-
Homo sapiens
3.5.4.5 3'-azido-3'-deoxythymidine
-
Homo sapiens
3.5.4.5 3-deazauridine
-
Homo sapiens
3.5.4.5 4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5 4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5 4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one
-
Homo sapiens
3.5.4.5 5,6-Dihydrouridine
-
Escherichia coli
3.5.4.5 5,6-Dihydrouridine
-
Homo sapiens
3.5.4.5 5-(Chloromercuri)cytidine
-
Escherichia coli
3.5.4.5 5-(Chloromercuri)cytidine
-
Homo sapiens
3.5.4.5 5-Bromouridine
-
Homo sapiens
3.5.4.5 5-fluoro-2'-deoxyuridine
-
Homo sapiens
3.5.4.5 5-fluorouridine
-
Homo sapiens
3.5.4.5 5-iodo-2'-deoxyuridine
-
Homo sapiens
3.5.4.5 5-methyluridine
-
Homo sapiens
3.5.4.5 5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine
-
Homo sapiens
3.5.4.5 6-azauridine
-
Homo sapiens
3.5.4.5 Ag+
-
Homo sapiens
3.5.4.5 ara-U
-
Homo sapiens
3.5.4.5 CMP
-
Homo sapiens
3.5.4.5 Cu2+
-
Escherichia coli
3.5.4.5 Cu2+
-
Homo sapiens
3.5.4.5 Cu2+
-
Mus musculus
3.5.4.5 dCMP
-
Homo sapiens
3.5.4.5 deoxyadenosine
-
Escherichia coli
3.5.4.5 deoxyadenosine
-
Homo sapiens
3.5.4.5 DTNB
-
Homo sapiens
3.5.4.5 DTNB
-
Mus musculus
3.5.4.5 dTTP
-
Homo sapiens
3.5.4.5 dTTP
-
Mus musculus
3.5.4.5 Hg+
-
Escherichia coli
3.5.4.5 Hg+
-
Homo sapiens
3.5.4.5 Hg+
-
Mus musculus
3.5.4.5 N-ethylmaleimide weak inhibition Homo sapiens
3.5.4.5 N-ethylmaleimide
-
Mus musculus
3.5.4.5 p-chloromercuribenzoate
-
Homo sapiens
3.5.4.5 pseudouridine
-
Homo sapiens
3.5.4.5 thymidine
-
Escherichia coli
3.5.4.5 thymidine
-
Homo sapiens
3.5.4.5 thymine riboside
-
Escherichia coli
3.5.4.5 thymine riboside
-
Homo sapiens
3.5.4.5 uridine
-
Escherichia coli
3.5.4.5 uridine
-
Homo sapiens
3.5.4.5 UTP
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.5 13500
-
4 * 13500, SDS-PAGE Homo sapiens
3.5.4.5 52000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.5 cytidine + H2O Gallus gallus
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Mus musculus
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Escherichia coli
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Homo sapiens
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Canis lupus familiaris
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Mus musculus BALB/c
-
uridine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.5 Canis lupus familiaris
-
-
-
3.5.4.5 Escherichia coli
-
-
-
3.5.4.5 Gallus gallus
-
chicken
-
3.5.4.5 Homo sapiens
-
human
-
3.5.4.5 Mus musculus
-
mouse
-
3.5.4.5 Mus musculus
-
BALB/c
-
3.5.4.5 Mus musculus BALB/c
-
BALB/c
-
3.5.4.5 no activity in Lactobacillus sp.
-
-
-
3.5.4.5 no activity in Moraxella sp.
-
Neisseria meningitidis
-
3.5.4.5 no activity in Pseudomonas sp.
-
P. acidovorans
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.5
-
Gallus gallus
3.5.4.5
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.5 granulocyte normal and leukemic Homo sapiens
-
3.5.4.5 liver
-
Gallus gallus
-
3.5.4.5 liver
-
Mus musculus
-
3.5.4.5 liver
-
Homo sapiens
-
3.5.4.5 liver
-
Canis lupus familiaris
-
3.5.4.5 lymphocyte
-
Homo sapiens
-
3.5.4.5 placenta
-
Homo sapiens
-
3.5.4.5 reticulocyte
-
Homo sapiens
-
3.5.4.5 spleen
-
Mus musculus
-
3.5.4.5 spleen
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.5 64.1
-
-
Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.5.4.5 -20°C, 20% glycerol appears to be necessary to prevent inactivation from occuring after freezing and thawing Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
Homo sapiens ?
-
?
3.5.4.5 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
Canis lupus familiaris ?
-
?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
Mus musculus ?
-
?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
Escherichia coli ?
-
?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
Homo sapiens ?
-
?
3.5.4.5 1-beta-D-arabinofuranosylcytosine + H2O
-
Canis lupus familiaris ?
-
?
3.5.4.5 2'-deoxycytidine + H2O
-
Mus musculus 2'-deoxyuridine + NH3
-
?
3.5.4.5 2'-deoxycytidine + H2O
-
Escherichia coli 2'-deoxyuridine + NH3
-
?
3.5.4.5 2'-deoxycytidine + H2O
-
Homo sapiens 2'-deoxyuridine + NH3
-
?
3.5.4.5 2'-deoxycytidine + H2O
-
Mus musculus BALB/c 2'-deoxyuridine + NH3
-
?
3.5.4.5 2'-fluoro-2'-deoxycytidine + H2O
-
Escherichia coli 2'-fluoro-2'-deoxyuridine + NH3
-
?
3.5.4.5 2'-fluoro-2'-deoxycytidine + H2O
-
Homo sapiens 2'-fluoro-2'-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Mus musculus 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Escherichia coli 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Homo sapiens 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Mus musculus BALB/c 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5-azacytidine + H2O
-
Escherichia coli 5-azauridine + NH3
-
?
3.5.4.5 5-azacytidine + H2O
-
Homo sapiens 5-azauridine + NH3
-
?
3.5.4.5 5-azadeoxycytidine + H2O
-
Homo sapiens 5-azadeoxyuridine + NH3
-
?
3.5.4.5 5-iodo-2'-deoxycytidine
-
Homo sapiens 5-iodo-2'-deoxyuridine + NH3
-
?
3.5.4.5 5-iododeoxycytidine + H2O
-
Mus musculus 5-iododeoxyuridine + NH3
-
?
3.5.4.5 5-iododeoxycytidine + H2O
-
Homo sapiens 5-iododeoxyuridine + NH3
-
?
3.5.4.5 5-methylcytidine + H2O
-
Escherichia coli 5-methyluridine + NH3
-
?
3.5.4.5 5-methylcytidine + H2O
-
Homo sapiens 5-methyluridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Gallus gallus uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Mus musculus uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Escherichia coli uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Homo sapiens uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Canis lupus familiaris uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Mus musculus BALB/c uridine + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Mus musculus uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Escherichia coli uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Homo sapiens uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Mus musculus BALB/c uridine arabinoside + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Mus musculus deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Escherichia coli deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Homo sapiens deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Canis lupus familiaris deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Mus musculus BALB/c deoxyuridine + NH3
-
?
3.5.4.5 additional information
-
Escherichia coli ?
-
?
3.5.4.5 additional information 3-methylcytidine, cytosine and cyclocytidine are no substrates Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.5 tetramer
-
Gallus gallus
3.5.4.5 tetramer 4 * 13500, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.5.4.5 cytidine/2'-deoxycytidine aminohydrolase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.5 7.5
-
-
Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.5 3.5 10.5 deoxycytidine as substrate, beyond these values irreversible inactivation occurs Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.5.4.5 3.5 10.5 deoxycytidine as substrate, beyond these extremes rapid inactivation Homo sapiens